SWISS-PROT: P12497

ID   POL_HV1N5      STANDARD;      PRT;  1003 AA.
AC   P12497;
DT   01-OCT-1989 (REL. 12, CREATED)
DT   01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE)
DT   01-JUL-1993 (REL. 26, LAST ANNOTATION UPDATE)
DE   POL POLYPROTEIN (PROTEASE (EC 3.4.23.-); REVERSE TRANSCRIPTASE
DE   (EC 2.7.7.49); RIBONUCLEASE H (EC 3.1.26.4)).
GN   POL.
OS   HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (NEW YORK-5 ISOLATE) (HIV-1).
OC   VIRIDAE; SS-RNA ENVELOPED VIRUSES; POSITIVE-STRAND; RETROVIRIDAE;
OC   LENTIVIRINAE.
RN   [1]
RP   CLONE PNL4-3, SEQUENCE FROM N.A.
RA   BUCKLER C.E., BUCKLER-WHITE A.J., WILLEY R.L., MCCOY J.;
RL   SUBMITTED (JUN-1988) TO THE HIV DATA BANK.
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 57-155.
RM   90354401 [MEDLINE, MEDLARS]
RA   FITZGERALD P.M.D., MCKEEVER B.M., VAN MIDDLESWORTH J.F.,
RA   SPRINGER J.P., HEIMBACH J.C., LEU C.-T., HERBER W.K., DIXON R.A.F.,
RA   DARKE P.L.;
RL   J. BIOL. CHEM. 265:14209-14219(1990).
CC   -!- CLEAVAGE SITES THAT YIELD THE MATURE PROTEINS REMAIN TO BE
CC       DETERMINED.
DR   EMBL; M19921; REHIVNL4.
DR   HIV; M19921; POL$NL43.
DR   PDB; 5HVP; 15-OCT-91. [ENTRY / 3D IMAGE]
DR   SWISS-3DIMAGE; POL_HV1N5. [MONO / STEREO]
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   AIDS; POLYPROTEIN; HYDROLASE; ASPARTYL PROTEASE; ENDONUCLEASE;
KW   RNA-DIRECTED DNA POLYMERASE; 3D-STRUCTURE.
FT   CHAIN        57    155       PROTEASE.
FT   ACT_SITE     81     81
FT   STRAND       58     60
FT   STRAND       66     71
FT   TURN         72     73
FT   STRAND       74     80
FT   TURN         82     83
FT   STRAND       87     90
FT   STRAND       99    105
FT   TURN        106    107
FT   STRAND      108    122
FT   TURN        123    124
FT   STRAND      125    134
FT   STRAND      140    141
FT   HELIX       143    149
FT   TURN        150    150
FT   STRAND      152    154
SQ   SEQUENCE   1003 AA;  113535 MW;  5204232 CN;
     FFREDLAFPQ GKAREFSSEQ TRANSPTRRE LQVWGRDNNS LSEAGADRQG TVSFSFPQIT
     LWQRPLVTIK IGGQLKEALL DTGADDTVLE EMNLPGRWKP KMIGGIGGFI KVGQYDQILI
     EICGHKAIGT VLVGPTPVNI IGRNLLTQIG CTLNFPISPI ETVPVKLKPG MDGPKVKQWP
     LTEEKIKALV EICTEMEKEG KISKIGPENP YNTPVFAIKK KDSTKWRKLV DFRELNKRTQ
     DFWEVQLGIP HPAGLKQKKS VTVLDVGDAY FSVPLDKDFR KYTAFTIPSI NNETPGIRYQ
     YNVLPQGWKG SPAIFQCSMT KILEPFRKQN PDIVIYQYMD DLYVGSDLEI GQHRTKIEEL
     RQHLLRWGFT TPDKKHQKEP PFLWMGYELH PDKWTVQPIV LPEKDSWTVN DIQKLVGKLN
     WASQIYAGIK VRQLCKLLRG TKALTEVVPL TEEAELELAE NREILKEPVH GVYYDPSKDL
     IAEIQKQGQG QWTYQIYQEP FKNLKTGKYA RMKGAHTNDV KQLTEAVQKI ATESIVIWGK
     TPKFKLPIQK ETWEAWWTEY WQATWIPEWE FVNTPPLVKL WYQLEKEPII GAETFYVDGA
     ANRETKLGKA GYVTDRGRQK VVPLTDTTNQ KTELQAIHLA LQDSGLEVNI VTDSQYALGI
     IQAQPDKSES ELVSQIIEQL IKKEKVYLAW VPAHKGIGGN EQVDGLVSAG IRKVLFLDGI
     DKAQEEHEKY HSNWRAMASD FNLPPVVAKE IVASCDKCQL KGEAMHGQVD CSPGIWQLDC
     THLEGKVILV AVHVASGYIE AEVIPAETGQ ETAYFLLKLA GRWPVKTVHT DNGSNFTSTT
     VKAACWWAGI KQEFGIPYNP QSQGVIESMN KELKKIIGQV RDQAEHLKTA VQMAVFIHNF
     KRKGGIGGYS AGERIVDIIA TDIQTKELQK QITKIQNFRV YYRDSRDPVW KGPAKLLWKG
     EGAVVIQDNS DIKVVPRRKA KIIRDYGKQM AGDDCVASRQ DED
//

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