ID TAT_HV1BR STANDARD; PRT; 86 AA. AC P04610; DT 13-AUG-1987 (REL. 05, CREATED) DT 13-AUG-1987 (REL. 05, LAST SEQUENCE UPDATE) DT 01-JUL-1993 (REL. 26, LAST ANNOTATION UPDATE) DE TAT PROTEIN (TRANSACTIVATING REGULATORY PROTEIN). GN TAT. OS HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (BRU ISOLATE) (HIV-1). OC VIRIDAE; SS-RNA ENVELOPED VIRUSES; POSITIVE-STRAND; RETROVIRIDAE; OC LENTIVIRINAE. RN [1] RP SEQUENCE FROM N.A. RM 85099333 [MEDLINE, MEDLARS] RA WAIN-HOBSON S., SONIGO P., DANOS O., COLE S., ALIZON M.; RL CELL 40:9-17(1985). RN [2] RP CLONE PNL4-3, SEQUENCE FROM N.A. RA BUCKLER C.E., BUCKLER-WHITE A.J., WILLEY R.L., MCCOY J.; RL SUBMITTED (JUN-1988) TO THE HIV DATA BANK. CC -!- FUNCTION: TAT IS AN EFFECTOR OF AN AUTOSTIMULATORY PATHWAY THROUGH CC INTERACTION WITH A POSITIVE CONTROL ELEMENT, THE TRANS-ACTIVATING CC RESPONSIVE SEQUENCE (TAR). CC -!- DELETION MUTANTS IN THE TAT GENE ARE INCAPABLE OF PROLIFIC CC REPLICATION AND EXHIBIT NO CYTOPATHIC EFFECTS IN T4+ CELL LINES. DR EMBL; K02013; HIVBRUCG. DR HIV; K02013; TAT$BRU. DR EMBL; M19921; REHIVNL4. DR HIV; M19921; TAT$NL43. DR SWISS-2DPAGE; GET REGION ON 2D PAGE. KW TRANSCRIPTION REGULATION; AIDS. FT VARIANT 24 24 T -> N (IN CLONE PNL4-3). FT VARIANT 39 39 T -> M (IN CLONE PNL4-3). FT VARIANT 58 61 PPQG -> AHQN (IN CLONE PNL4-3). FT VARIANT 67 67 V -> A (IN CLONE PNL4-3). FT VARIANT 77 77 P -> S (IN CLONE PNL4-3). SQ SEQUENCE 86 AA; 9769 MW; 39202 CN; MEPVDPRLEP WKHPGSQPKT ACTTCYCKKC CFHCQVCFTT KALGISYGRK KRRQRRRPPQ GSQTHQVSLS KQPTSQPRGD PTGPKE //
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