ID POL_HV1N5 STANDARD; PRT; 1003 AA. AC P12497; DT 01-OCT-1989 (REL. 12, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 01-JUL-1993 (REL. 26, LAST ANNOTATION UPDATE) DE POL POLYPROTEIN (PROTEASE (EC 3.4.23.-); REVERSE TRANSCRIPTASE DE (EC 2.7.7.49); RIBONUCLEASE H (EC 3.1.26.4)). GN POL. OS HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (NEW YORK-5 ISOLATE) (HIV-1). OC VIRIDAE; SS-RNA ENVELOPED VIRUSES; POSITIVE-STRAND; RETROVIRIDAE; OC LENTIVIRINAE. RN [1] RP CLONE PNL4-3, SEQUENCE FROM N.A. RA BUCKLER C.E., BUCKLER-WHITE A.J., WILLEY R.L., MCCOY J.; RL SUBMITTED (JUN-1988) TO THE HIV DATA BANK. RN [2] RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 57-155. RM 90354401 [MEDLINE, MEDLARS] RA FITZGERALD P.M.D., MCKEEVER B.M., VAN MIDDLESWORTH J.F., RA SPRINGER J.P., HEIMBACH J.C., LEU C.-T., HERBER W.K., DIXON R.A.F., RA DARKE P.L.; RL J. BIOL. CHEM. 265:14209-14219(1990). CC -!- CLEAVAGE SITES THAT YIELD THE MATURE PROTEINS REMAIN TO BE CC DETERMINED. DR EMBL; M19921; REHIVNL4. DR HIV; M19921; POL$NL43. DR PDB; 5HVP; 15-OCT-91. [ENTRY / 3D IMAGE] DR SWISS-3DIMAGE; POL_HV1N5. [MONO / STEREO] DR SWISS-2DPAGE; GET REGION ON 2D PAGE. KW AIDS; POLYPROTEIN; HYDROLASE; ASPARTYL PROTEASE; ENDONUCLEASE; KW RNA-DIRECTED DNA POLYMERASE; 3D-STRUCTURE. FT CHAIN 57 155 PROTEASE. FT ACT_SITE 81 81 FT STRAND 58 60 FT STRAND 66 71 FT TURN 72 73 FT STRAND 74 80 FT TURN 82 83 FT STRAND 87 90 FT STRAND 99 105 FT TURN 106 107 FT STRAND 108 122 FT TURN 123 124 FT STRAND 125 134 FT STRAND 140 141 FT HELIX 143 149 FT TURN 150 150 FT STRAND 152 154 SQ SEQUENCE 1003 AA; 113535 MW; 5204232 CN; FFREDLAFPQ GKAREFSSEQ TRANSPTRRE LQVWGRDNNS LSEAGADRQG TVSFSFPQIT LWQRPLVTIK IGGQLKEALL DTGADDTVLE EMNLPGRWKP KMIGGIGGFI KVGQYDQILI EICGHKAIGT VLVGPTPVNI IGRNLLTQIG CTLNFPISPI ETVPVKLKPG MDGPKVKQWP LTEEKIKALV EICTEMEKEG KISKIGPENP YNTPVFAIKK KDSTKWRKLV DFRELNKRTQ DFWEVQLGIP HPAGLKQKKS VTVLDVGDAY FSVPLDKDFR KYTAFTIPSI NNETPGIRYQ YNVLPQGWKG SPAIFQCSMT KILEPFRKQN PDIVIYQYMD DLYVGSDLEI GQHRTKIEEL RQHLLRWGFT TPDKKHQKEP PFLWMGYELH PDKWTVQPIV LPEKDSWTVN DIQKLVGKLN WASQIYAGIK VRQLCKLLRG TKALTEVVPL TEEAELELAE NREILKEPVH GVYYDPSKDL IAEIQKQGQG QWTYQIYQEP FKNLKTGKYA RMKGAHTNDV KQLTEAVQKI ATESIVIWGK TPKFKLPIQK ETWEAWWTEY WQATWIPEWE FVNTPPLVKL WYQLEKEPII GAETFYVDGA ANRETKLGKA GYVTDRGRQK VVPLTDTTNQ KTELQAIHLA LQDSGLEVNI VTDSQYALGI IQAQPDKSES ELVSQIIEQL IKKEKVYLAW VPAHKGIGGN EQVDGLVSAG IRKVLFLDGI DKAQEEHEKY HSNWRAMASD FNLPPVVAKE IVASCDKCQL KGEAMHGQVD CSPGIWQLDC THLEGKVILV AVHVASGYIE AEVIPAETGQ ETAYFLLKLA GRWPVKTVHT DNGSNFTSTT VKAACWWAGI KQEFGIPYNP QSQGVIESMN KELKKIIGQV RDQAEHLKTA VQMAVFIHNF KRKGGIGGYS AGERIVDIIA TDIQTKELQK QITKIQNFRV YYRDSRDPVW KGPAKLLWKG EGAVVIQDNS DIKVVPRRKA KIIRDYGKQM AGDDCVASRQ DED //
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