SWISS-PROT: NEF_HV1BN

ID   NEF_HV1BN      STANDARD;      PRT;   218 AA.
AC   P12479;
DT   01-OCT-1989 (REL. 12, CREATED)
DT   01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE)
DT   01-JUL-1993 (REL. 26, LAST ANNOTATION UPDATE)
DE   NEGATIVE FACTOR (F-PROTEIN) (27 KD PROTEIN) (3'ORF).
GN   NEF.
OS   HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (BRAIN ISOLATE) (HIV-1).
OC   VIRIDAE; SS-RNA ENVELOPED VIRUSES; POSITIVE-STRAND; RETROVIRIDAE;
OC   LENTIVIRINAE.
RN   [1]
RP   SEQUENCE FROM N.A.
RM   89085613 [MEDLINE, MEDLARS]
RA   ANAND R., THAYER R., SRINIVASAN A., NAYYAR S., GARDNER M., LUCIW P.,
RA   DANDEKAR S.;
RL   VIROLOGY 168:79-89(1989).
CC   -!- FUNCTION: NEF HAS GTPASE, GTP-BINDING AND AUTOPHOSPHORYLATING
CC       ACTIVITIES, IT SEEM TO DOWN REGULATE THE CD4(T4) ANTIGEN.
CC   -!- THIS VIRUS IS CYTOPATHICALLY ACTIVE AND WAS HARVESTED FROM THE
CC       BRAIN TISSUE OF A NEUROLOGICAL AIDS PATIENT.
DR   EMBL; M21098; REHIVBRV.
DR   HIV; M21098; NEF$BRVA.
DR   PIR; D31667; ASLJBR.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   AIDS; MYRISTYLATION; GTP-BINDING.
FT   LIPID         2      2       MYRISTATE (BY SIMILARITY).
SQ   SEQUENCE   218 AA;  25032 MW;  239533 CN;
     MGGKWSKMAG WSTVRERMRR AEPARERMRR AEPRAEPAAD GVGAVSRDLE KHGAITSSNT
     AATNADCAWL EAQEDEEVGF PVKPQVPLRP MTYKAAVDLS HFLKEKGGLE GLIHSQQRQD
     ILDLWVYHTQ GYFPDWQNYT PGPGVRYPLT FGWCFKLVPV EPEKIEEANE GENNSLLHPM
     SQHGMDDPER EVLQWRFDSR LAFHHMAREL HPEYYKNC
//

Back to ExPASy Molecular Biology Server